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1 Morningstar Ratings: The Star Ratings as of October 31, 2022 for Series F for the Manulife Emerging Markets Fund, and the number of funds within their categories for each period are as follows: -34.64% (1 year), -4.83% (3 years), -2.44% (5 years) and 1.22% (since inception on May 26, 2014). The corresponding Morningstar ratings of the fund for the same period are as follows: N/A (1 year), 2 (3 years) [249 funds], 3 (5 years) [197 funds]. As of October 31, 2022, this fund has an overall 3-star rating from Morningstar.

2 Morningstar Ratings: The Star Ratings as of October 31, 2022 for Series F for the Manulife Global Thematic Opportunities Fund, and the number of funds within their categories for each period are as follows: -20.81% (1 year), 1.14% (3 years) and 4.73% (since inception on October 11, 2018). The corresponding Morningstar ratings of the fund for the same period are as follows: N/A (1 year), 2 (3 years) [1624 funds]. As of October 31, 2022, this fund has an overall 2-star rating from Morningstar.

3 Morningstar Ratings: The Star Ratings as of October 31, 2022 for Series F for the Manulife Strategic Income Fund, and the number of funds within their categories for each period are as follows: -11.23% (1 year), -1.75% (3 years), 0.25% (5 years), 3.13% (10 years) and 5.00% (since inception on January 11, 2007). The corresponding Morningstar ratings of the fund for the same period are as follows: N/A (1 year), 4 (3 years) [409 funds], 4 (5 years) [292 funds], 5 (10 years) [99 funds]. As of October 31, 2022, this fund has an overall 5-star rating from Morningstar.

4 Morningstar Ratings: The Star Ratings as of October 31, 2022 for Series F for the Manulife Yield Opportunities Fund, and the number of funds within their categories for each period are as follows: -12.36% (1 year), 0.58% (3 years), 2.04% (5 years), 4.74% (10 years) and 5.32% (since inception on December 23, 2009). The corresponding Morningstar ratings of the fund for the same period are as follows: N/A (1 year), 4 (3 years) [689 funds], 4 (5 years) [539 funds], 5 (10 years) [213 funds]. As of October 31, 2022, this fund has an overall 5-star rating from Morningstar.