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1 Morningstar Ratings: The Star Ratings as of April 30, 2022 for Series F for the Manulife Emerging Markets Fund, and the number of funds within their categories for each period are as follows: -29.42% (1 year), -1.25% (3 years), 2.24% (5 years) and 2.87% (since inception on May 26, 2014). The corresponding Morningstar ratings of the fund for the same period are as follows: N/A (1 year), 2 (3 years) [252 funds], 3 (5 years) [193 funds]. As of April 30, 2022, this fund has an overall 3-star rating from Morningstar.

2 Morningstar Ratings: The Star Ratings as of April 30, 2022 for Series F for the Manulife Global Thematic Opportunities Fund, and the number of funds within their categories for each period are as follows: -14.98% (1 year), 3.92% (3 years) and 6.95% (since inception on October 11, 2018). The corresponding Morningstar ratings of the fund for the same period are as follows: N/A (1 year), 2 (3 years) [1659 funds]. As of April 30, 2022, this fund has an overall 2-star rating from Morningstar.

3 Morningstar Ratings: The Star Ratings as of April 30, 2022 for Series F for the Manulife Strategic Income Fund, and the number of funds within their categories for each period are as follows: -6.31% (1 year), 1.11% (3 years), 1.57% (5 years), 4.15% (10 years) and 5.50% (since inception on January 11, 2007). The corresponding Morningstar ratings of the fund for the same period are as follows: N/A (1 year), 4 (3 years) [407 funds], 5 (5 years) [288 funds], 5 (10 years) [80 funds]. As of April 30, 2022, this fund has an overall 5-star rating from Morningstar.

4 Morningstar Ratings: The Star Ratings as of April 30, 2022 for Series F for the Manulife Yield Opportunities Fund, and the number of funds within their categories for each period are as follows: -5.45% (1 year), 2.86% (3 years), 3.51% (5 years), 5.74% (10 years) and 5.96% (since inception on December 23, 2009). The corresponding Morningstar ratings of the fund for the same period are as follows: N/A (1 year), 4 (3 years) [633 funds], 5 (5 years) [458 funds], 5 (10 years) [194 funds]. As of April 30, 2022, this fund has an overall 5-star rating from Morningstar.